Overview

Advanced stage breast cancer (stages III and IV) rates in the Pacific are much higher than in the USA mainland, especially where mammography services do not exist or have low accessibility. Hawaii and Guam both have high insurance coverage and mammography access similar to the United States mainland, but have much higher advanced stage rates, 60% and 15% for Guam and Hawaii, respectively, compared to 10% for women in Northern California. Further, the advanced staging in Hawaii dramatically varies by race/ethnicity with a high of 17% (Hawaiian) and a low of 10% (Japanese). The reason for these disparities across ethnicities in Hawaii and the larger Pacific is not well understood but clearly multifactorial.

Objective/Aims

Our overall hypothesis is that introducing portable handheld ultrasound (US) systems coupled with an artificial intelligence (AI) detection algorithm and operated by a trained healthcare worker will reduce advanced stage cancer rates in areas where mammography is not available.

For this to be true, the US screening approach would have to have similar sensitivity and specificity for breast cancer detection as screening mammography read by a radiologist. This approach would be very low cost and could also be extended to be used for point of care breast biopsies.

Our overall objective is to reduce the mortality of breast cancer in the Pacific by reducing the advanced breast cancer stage rate, resulting in a reduced burden of cancer. We believe the primary cause of very high advanced stage breast cancer is the lack of mammographic screening. If successful, the implementation of our paradigm could reduce overall breast cancer mortality rates by identifying breast cancers earlier, when they are more responsive to treatment.

Our specific aim is to identify cofactors (breast density, ethnicity, BMI, etc.) that impact the sensitivity and specificity for malignant breast cancer lesion detection on clinical ultrasound images with AI support for the following readers: 1) Radiologists, 2) Non-radiologist Doctor, and 3) Graduate Research Assistants (surrogate healthcare worker).

Research Team

Jami Fukui

Principal Investigator

UH Cancer Center

Dustin Valdez

Graduate Student Assistant

UH Mānoa/UHCC

John Shepherd, PhD

Co-Principal Investigator/Mentor

UH Cancer Center

Thomas Wolfgruber

IT Support

UH Cancer Center

Funding Source(s)

UH Cancer Center Seed Grant
This grant is funded by the UH Cancer Center’s P30 support grant.
01/01/2021 – 12/31/2021